Bcl-2 (Apoptosis regulator Bcl-2, B Cell CLL/lymphoma-2) (PE)

Catalogue Number: 168647-PE-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with R-Phycoerythrin (PE).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	100/D5+124
Isotype:
Immunogen:	Synthetic peptide corresponding to aa41-54, GAAPAPGIFSSQPG-Cys, from human Bcl-2. Cellular Localization: Outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes.
Application:	IF, IP, WB, IHC

Overview
Datasheets

Description

Description: This antibody recognizes a protein of 25-26kDa, identified as the bcl-2alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

BCL2

Gene ID

596

Uniprot ID

P10415

Purification

Protein A/G Purified

Specificity

Recognizes human Bcl-2. Does not react with mouse and rat. Does not react with Bcl-x or Bax protein.

Antibody Clonality

Monoclonal

168647-PE Datasheet

Price

£883.00

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