Cyclin A (CCN1, CCNA, CCNA2, Cyclin A2) (BSA & Azi168744-AFde Free) (MaxLight 650)
Catalogue Number: 168744-AF-ML650-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™650. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | E67 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Full length bovine Cyclin A protein. Cellular Localization: Predominantly nuclear. |
| Application: | FC, IF, WB, IHC, FLISA |
Description
Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.
Additional Text
Purification
Protein A/G Purified
Specificity
Recognizes bovine Cyclin A at ~54kD. Its epitope is located amino acids 144-148 of human Cyclin A2. Species Crossreactivity: mouse, human, african green monkey and mink.
Antibody Clonality
Monoclonal
168744-AF-ML650 Datasheet
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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