Cytokeratin 8 (CARD2, CK8, CYK8, CYKER, Cytokeratin Endo A, DreK8, EndoA, K2C8, K8, Keratin 8, Krt 2.8, KRT8, Type-II Keratin Kb8) (MaxLight 490)

Catalogue Number: 168754-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CARD2\|CK8\|CK-8\|CYK8\|cytokeratin-8\|K2C8\|K8\|keratin 8, type II\|keratin, type II cytoskeletal 8\|KO\|type-II keratin Kb8
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	H1, TS1
Isotype:	IgG1
Immunogen:	Cytoskeleton preparation containing cytokeratin 8 (H1); Keratin preparation from a human carcinoma (TS1). Cellular Localization: Cytoplasmic
Application:	IF, IP, WB, IHC

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular ("ring-like, perinuclear") from ductal ("peripheral-predominant") carcinoma of the breast.

Additional Text

Gene Name

KRT8

Gene ID

3856

Uniprot ID

P05787

Purification

Protein A/G Purified

Specificity

Recognizes human Cytokeratin 8. Species Crossreactivity: rat, and zebrafish. Others not known.

Antibody Clonality

Monoclonal

168754-ML490 Datasheet

Price

£883.00

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Quantity
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