Ep-CAM (CD326)
Catalogue Number: 169026-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 0.09% sodium azide. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rat |
| Clone: | G8.8 |
| Isotype: | IgG2a |
| Immunogen: | Glycoconjugates from Balb/C mouse derived medullary thymic epithelial cells. |
| Application: | FC, ICC, IP, WB, IHC |
Description
Description: Ep-CAM is a 40kD glycoprotein and can be detected at the basolateral membrane of the majority of epithelial tissues, where it is intricately linked with the cadherin-catenin complex and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. This antigen functions as a homotypic calcium-independent cell adhesion molecule. Of particular interest, Ep-CAM appears to be overexpressed by the majority of human epithelial carcinomas, including colorectal, breast, prostate, head and neck, and hepatic carcinomas. The antigen is being used as a target for immunotherapy of human carcinomas. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation.
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Recognizes mouse Ep-CAM.
Purification
Purified
Antibody Clonality
Monoclonal
169026 Datasheet
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