SARS-CoV-2 Inhibitor Screening Kit
Catalogue Number: 17-3001-ABO
| Manufacturer: | Abeomics |
| Type: | Enzyme Assays |
| Alias: | 2019-nCoV Inhibitor Screening Kit|2019-nCoV Spike Protein S1 (RBD)/ACE2 Inhibitor Screening Kit|COVID-19 Inhibitor Screening Kit |
| Shipping Condition: | Blue Ice |
| Unit(s): | 6 x 16 tests |
| Application: | FA |
Description
Description: Coronaviruses (CoVs) are enveloped non-segmented positive-sense single-stranded RNA viruses and can infect respiratory, gastrointestinal, hepatic and central nervous system of human and many other wild animals. Recently, a new severe acute respiratory syndrome beta-coronavirus called SARS-CoV-2 (or 2019-nCoV) has emerged, which causes an epidemic of acute respiratory syndrome (called coronavirus human disease 2019 or COVID-19).SARS-CoV-2 contains 4 structural proteins, including Envelope (E), Membrane (M), Nucleocapsid (N) and Spike (S), which is a transmembrane protein, composed of two subunits S1 and S2. The S1 subunit contains a receptor binding domain (RBD), which binds to the cell surface receptor. Angiotensin-Converting Enzyme 2 (ACE2) present at the surface of epithelial cells, causing mainly infection of human respiratory cells.
Additional Text
Application Notes
This inhibitor screening assay is based on a colorimetric ELISA kit, which measures the binding of the RBD of the Spike S protein from SARS-CoV-2 to its human receptor ACE2. Thus, this assay allows to identify and characterize the effect of different inhibitory molecules including antibodies or chemicals on the inhibition of the binding of SARS-CoV-2 virus to human ACE2.
17-3001 Protocol
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