PDCD1 (Programmed Cell Death Protein 1, Protein PD-1, hPD-1, CD279, PD1)

Catalogue Number: 171125-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in aqueous buffer, 0.09% sodium azide.May contain carrier protein/stabilizer.
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	50 ug
Host name:	Mouse
Clone:	J116
Isotype:	IgG1, kappa
Immunogen:
Application:	ELISA, FC, IP, WB, IHC, NT

Overview
Datasheets

Description

Description: PD-1 (programmed death-1) is a 55kD member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

PDCD1

Gene ID

5133

Uniprot ID

Q15116

Specificity

Recognizes human PDCD1.

Purification

Affinity Purified

Antibody Clonality

Monoclonal

171125 Datasheet

Price

£530.00

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