Papilloma Virus Type 16 (HPV16, L1, Capsid L1, HPV, HPV Type 16, Late Protein 1) (HRP)

Catalogue Number: 171712-HRP-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	14D147
Isotype:	IgG2a, kappa
Immunogen:	Beta galactosidase-L1 fusion protein.
Application:	IP, WB, IHC

Overview
Datasheets

Description

Description: Specific types of HPV have been shown to be associated with human cervical cancer. One of these types, HPV16, has been shown to be present in the majority of cervical dysplasias and squamous cell carcinomas studied. Research has also shown that the expression of the HPV16-E7 gene is both sufficient and necessary for cellular transformation in vitro. The immunological detection of HPV types in human samples has been hindered by the lack of an in vitro culture system for the propagation of viruses and viral antigens. Although antibodies that were generated against the bovine papillomavirus capsid antigen (BPV-L1 ORF) are cross-reactive to HPV, these antibodies are of limited use because they do not discriminate among HPV types and have limited sensitivity as compared to standard light microscopic criteria for HPV infection. With bacterial expression systems, fusion proteins of HPV-encoded gene products can be generated and these, in turn, used to develop HPV type specific antibodies. The use of these type specific antibodies to study HPV protein expression may expand understanding of the role of HPV proteins in the pathogenesis of condylomas, dysplasias, and carcinomas of the genital tract.

Additional Text

Purification

Protein A purified

Antibody Clonality

Monoclonal

171712-HRP Datasheet

Price

£992.00

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