BCL10 (B Cell CLL/lymphoma 10, B Cell Leukemia/lymphoma 10, CARD-containing Molecule enhancing NF-kappa-B, CARD-like apoptotic Protein, caspase-recruiting domain-containing Protein, CED-3/ICH-1 Prodomain Homologous E10-like Regulator, Cellular Homolog of
Catalogue Number: 172034-AF-HRP-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with horseradish peroxidase (HRP). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | SPM520 |
| Isotype: | IgG1, kappa |
| Immunogen: | Human BCL10 recombinant protein (epitope aa122-168). Cellular Localization: Nuclear and cytoplasmic |
| Application: | ELISA, IP, WB, IHC |
Description
Description: BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NFκB activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Additional Text
Gene Name
BCL10
Gene ID
8915
Uniprot ID
O95999
Purification
Protein A/G Purified
Specificity
Recognizes human BCL10.
Antibody Clonality
Monoclonal
Full Name
BCL10 (B Cell CLL/lymphoma 10, B Cell Leukemia/lymphoma 10, CARD-containing Molecule enhancing NF-kappa-B, CARD-like apoptotic Protein, caspase-recruiting domain-containing Protein, CED-3/ICH-1 Prodomain Homologous E10-like Regulator, Cellular Homolog of vCARMEN, Cellular-E10, cE10, CIPER, hCLAP, mE10, R-RCD1) (HRP)
172034-AF-HRP Datasheet
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