Carcinoembryonic Antigen (Carcinoembryonic Antigen-related Cell Adhesion Molecule 5, CEACAM5, CD66, Biliary GlycoProtein, BGP-1, CEA) (HRP)

Catalogue Number: 172040-AF-HRP-USB

Manufacturer:United States Biological
Physical state:Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with horseradish peroxidase (HRP).
Type:Monoclonal Primary Antibody - Conjugated
Alias:carcinoembryonic antigen-related cell adhesion molecule 5|CD66e|CEA|meconium antigen 100
Shipping Condition:Blue Ice
Unit(s): 100 ul
Host name: Mouse
Clone: SPM541
Isotype: IgG1, kappa
Immunogen: Human colon carcinoma extract. Cellular Localization: Cytoplasmic and luminal surface
Application: ELISA, IP, WB, IHC

Description

Description: This antibody recognizes proteins of 80-200kD, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb reacts with nonspecific cross-reacting antigen (NCA) and shows a cross-reaction with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.

Additional Text

Gene Name

CEACAM5

Gene ID

1048

Uniprot ID

P06731

Purification

Protein A/G Purified

Specificity

Recognizes Carcinoembryonic Antigen. Species Crossreactivity: Human and Monkey

Antibody Clonality

Monoclonal