CD45 (B220, CD45R, GP180, Leukocyte common antigen, LCA, Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C, PTPRC, Receptor-type tyrosine-Protein phosphatase C, T200 GlycoProtein) (HRP)

Catalogue Number: 172051-HRP-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with horseradish peroxidase (HRP).
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	B220\|CD45\|CD45 antigen\|CD45R\|GP180\|LCA\|L-CA\|LY5\|protein tyrosine phosphatase, receptor type, c polypeptide\|receptor-type tyrosine-protein phosphatase C\|T200\|T200 glycoprotein\|T200 leukocyte common antigen
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	SPM569 + SPM570
Isotype:	IgG1, kappa
Immunogen:	Isolated neoplastic cells from T cell lymphoma (2B11); and human peripheral blood lymphocytes maintained in T cell growth factor (PD7/26). Cellular Localization: Cell surface and cytoplasmic
Application:	IP, WB, IHC

Overview
Datasheets

Description

Description: Recognizes the CD45 leukocyte common antigen (LCA) family which is comprised of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kD) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

PTPRC

Gene ID

5788

Uniprot ID

P08575

Purification

Protein A/G Purified

Specificity

Recognizes human CD45.

Antibody Clonality

Monoclonal

172051-HRP Datasheet

Price

£883.00

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