CD79a (B lymphocyte-specific MB1 Protein, B Cell antigen receptor complex-Associated Protein alpha chain, CD79a Molecule immunoglobulin Associated alpha, Ig-alpha, IGA, IgM-alpha, Immunoglobulin-Associated alpha, Ly54, MB-1 Membrane GlycoProtein, Membrane

Catalogue Number: 172065-AF-BIOTIN-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Biotin.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	SPM550
Isotype:	IgG1, kappa
Immunogen:	Synthetic peptide corresponding to aa202-216 (GTYQDVGSLNIADVQ) of human CD79a. Cellular Localization: Cell surface
Application:	ELISA, IF, IP, WB, IHC

Overview

Description

Description: A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

Additional Text

Gene ID

973

Gene Name

CD79A

Uniprot ID

P11912

Purification

Protein A/G Purified

Specificity

Recognizes human CD79a. Species Crossreactivity: monkey, porcine, bovine, mouse, rat

Antibody Clonality

Monoclonal

Full Name

CD79a (B lymphocyte-specific MB1 protein, B Cell antigen receptor complex-associated protein alpha chain, CD79a molecule immunoglobulin associated alpha, Ig-alpha, IGA, IgM-alpha, Immunoglobulin-associated alpha, Ly54, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein) (Biotin)

Price

£883.00

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