Chromogranin A (Beta-Granin, CGA, CHGA, Chromogranin A Parathyroid Secretory Protein 1, ER-37, Pancreastatin, Parastatin, Parathyroid Secretory Protein 1, Pituitary Secretory Protein I, SP-I, Vasostatin I or II) (Biotin)

Catalogue Number: 172068-AF-BIOTIN-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Biotin.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	betagranin (N-terminal fragment of chromogranin A)\|catestatin\|CGA\|chromofungin\|chromogranin-A\|parathyroid secretory protein 1\|pituitary secretory protein I\|SP-I
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	SPM585
Isotype:	IgG1, kappa
Immunogen:	Human pheochromocytoma. Cellular Localization: Finely granular cytoplasmic
Application:	ELISA, IF, IP, WB, IHC

Overview

Description

Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Additional Text

Gene ID

1113

Gene Name

CHGA

Uniprot ID

P10645

Purification

Protein A/G Purified

Specificity

Recognizes Chromogranin A. Species Crossreactivity: Human, Monkey. Does not react with mouse and rat.

Antibody Clonality

Monoclonal

Price

£883.00

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