MUC5AC (Apomucin Major Airway GlycoProtein, Mucin 5 subtype AC tracheobronchial, Mucin 5 Subtypes A And C, Mucin 5AC oligomeric mucus/gel forming, Tracheobronchial Mucin, TBM, Mucin 5AC, Gastric Mucin) (BSA & Azide Free) (MaxLight 490)
Catalogue Number: 172129-AF-ML490-USB
| Manufacturer: | United States Biological |
| Preservative: | BSA & Azide Free |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | SPM297 |
| Isotype: | IgG1, kappa |
| Immunogen: | M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient. Cellular Localization: Cytoplasmic |
| Application: | FC, IF, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. This MAb recognizes the peptide core of gastric mucin M1 (>1,000kD) (recently identified as Mucin 5AC). Its epitope is destroyed by beta-mercaptoethanol and proteases but not by periodate treatment. Antibody to gastric mucin M1 reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous and cancerous colon but not with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.
Additional Text
Gene Name
MUC5AC
Purification
Protein A/G Purified
Specificity
Recognizes the peptide core of gastric mucin M1 (>1000kD) (recently identified as Mucin 5AC) MUC5AC. Its epitope is destroyed by beta-mercaptoethanol and proteases but not by periodate treatment. Species Crossreactivity: human, monkey, rabbit, feline, mouse, rat, porcine, hedgehog, chicken. Does not react with bovine.
Gene ID
4586
Uniprot ID
P98088
Antibody Clonality
Monoclonal
172129-AF-ML490 Datasheet
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