Anti-Human c-Ret (Long Isoform) Rabbit IgG Affinity Purify

Catalogue Number: 18128-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 200 ug, 10 ug
Host name:
Clone:
Isotype:
Immunogen: Synthetic peptide of the C-terminal part of Human c-Ret Long Isoform(ANWMLSPSAAKLMDTFDS)

Description

Description: The ret proto-oncogene products (proto-Ret protein) are expressed as 150kDa and 170kDa glycoproteins in neuroblastoma cells and as 150kDa and 190kDa glycoproteins in leukemia cells. These proteins are produced from a single polypeptide of 120kDa by posttranslational glycosylation. Although expression of the ret proto-oncogene was frequently detected in human tumors such as neuroblastoma, pheochromocytoma and thyroid medullary carcinoma, its physiological function is unknown. It turned out that the extracellular domain of the proto-Ret protein contains a cadherin-related sequence that is known to be important for Ca2+-dependent homophilic binding of cadherins. The homologous sequence found in the proto-Ret protein consists of about 110 amino acids and is tandemly repeated 3 - 4 times in the extracellular domains of all vertebrate cadherins. The sequence of the proto-Ret protein showed 20-30% identity with the member of the cadherin superfamily in the amino acid level. This suggests that possibility that the proto-Ret protein may function as a cell adhesion molecule like cadherins.

Additional Text

Specificity

Long Isoform specific.

Price
280.00


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