Catalogue Number: 18128-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Physical state:||Lyophilized product in PBS containing 1 % BSA and 0.05 % NaN3|
|Type:||Polyclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Unit(s):||200 ug, 10 ug|
|Immunogen:||Synthetic peptide of the C-terminal part of Human c-Ret Long Isoform(ANWMLSPSAAKLMDTFDS)|
Description: The ret proto-oncogene products (proto-Ret protein) are expressed as 150kDa and 170kDa glycoproteins in neuroblastoma cells and as 150kDa and 190kDa glycoproteins in leukemia cells. These proteins are produced from a single polypeptide of 120kDa by posttranslational glycosylation. Although expression of the ret proto-oncogene was frequently detected in human tumors such as neuroblastoma, pheochromocytoma and thyroid medullary carcinoma, its physiological function is unknown. It turned out that the extracellular domain of the proto-Ret protein contains a cadherin-related sequence that is known to be important for Ca2+-dependent homophilic binding of cadherins. The homologous sequence found in the proto-Ret protein consists of about 110 amino acids and is tandemly repeated 3 - 4 times in the extracellular domains of all vertebrate cadherins. The sequence of the proto-Ret protein showed 20-30% identity with the member of the cadherin superfamily in the amino acid level. This suggests that possibility that the proto-Ret protein may function as a cell adhesion molecule like cadherins.
Long Isoform specific.