Anti-Human HGFα (H163) Rabbit IgG Affinity Purify

Catalogue Number: 18133-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Synthetic peptide of Human HGF α-chain (LPSSYRGKDLQENYC)
Application: WB, IHC

Description

Description: Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid that is processed to generate the mature growth factor consisting of a disulfide-linked 69 kDa α 34 kDa β chain.