Catalogue Number: 18515-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Physical state:||Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3|
|Type:||Polyclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Unit(s):||100 ug, 10 ug|
|Immunogen:||Synthetic peptide of a part of Human COX-2|
Description: COX-1 and COX-2 (Cyclooxygenase 1,2) are also called prostaglandin endoperoxide H synthase, and are important enzymes as catalysts for the reaction in prostaglandin H2 (PGH2) synthesis from the arachidonic acid. COX-1 and COX-2 have the homology of about 60% at the amino acid level. COX-1 is expressed constitutively in many organs such as kidney, stomach, vascular smooth muscle or platelets widely and it is thought to play a so-called housekeeping role. On the other hand, COX-2 cannot be usually detected from organs, however, it is high-level expressed by macrophage and other cells in response to the stimulation such as various cytokines, hormones, the tumor cause medicines, inflammation mediators, or mitogens, therefore, it is thought that COX-2 produces prostaglandin in relation to the inflammation condition.
Human COX-2 specific. Not cross-react with Human COX-1 and Rat COX-2. Reacts with U937 cell line stimulated with TPA.