Anti-Human 14-3-3 σ Protein (69) Rabbit IgG Affinity Purify

Catalogue Number: 18640-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 100 ug, 10 ug
Host name:
Clone:
Isotype:
Immunogen: Synthetic peptide of intermediate portion of human 14-3-3 sigma protein (SNEEGSEEKGPEV)

Description

Description: The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. This plethora of interacting proteins allows 14-3-3 to play important roles in a wide range of vital regulatory processes, such as mitogenic signal transduction, apoptotic cell death, and cell cycle control. The cell cycle checkpoint plays an important role in maintaining the integrity of cells. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/SDI1, but the basis for the G2 arrest is unknown. Recently, one of the 14-3-3 protein family members, 14-3-3sigma, was shown to be regulated by p53 and to play a role in the G2-M-phase checkpoint. 14-3-3 sigma was cloned by expression cloning through cyclin-dependent kinase 2 (CDK2) association. 14-3-3 sigma shares cyclin-CDK2 binding motifs with different cell cycle regulators, including p107, p130, p21 (CIP1), p27 (KIP1), and p57 (KIP2), and is associated with cyclin.

Additional Text

Specificity

Human 14-3-3 sigma specific. Does not cross-react with 14-3-3 Beta, Gamma, Epsilon, Zeta, Eta, and Tau. (Confirmed by western blotting.)

Price
280.00


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