Anti-Human NFκB p65 (C) Rabbit IgG Affinity Purify

Catalogue Number: 18667-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ug, 10 ug
Host name: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of the C terminal part of Human NF kappa B p65 (SIADMDFSALLSQISS)
Application: WB, IHC


Description: In 1986, a transcription factor binding to an enhancer region that is necessary to express immunoglobulin κ light chain gene on mature B cells specifically was identified, and it was named nuclear factor κB (NFκB, nuclear factor of kappa light chain gene enhancer in B cells). Afterwards, it was clarified that NFκB is two hetero dimeric forms of p50 and p65, and it was also found that each molecule has high homology with c-Rel (oncoprotein of avian retrovirus (reticuloendotheliosis virus strain T) that induces a tumor to the spleen) by cDNA cloning. Nowadays, NFκB is classified into Rel family proteins. In a cell signaling system, NFκB forms a complex with IκB in the cytoplasm, and it is inactivated. It is thought that NF-κB is a transcription factor distributed in many kinds of cells. It shifts to the nucleus by IκB's being dissolved along with various stimulation, and then controls the expressions of various genes.


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