Anti-Human Sir2/SIRT1 Rabbit IgG Affinity Purify

Catalogue Number: 18761-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 100 ug, 10 ug
Host name:
Immunogen: Synthetic peptides of the part of C-terminal of human Sir2/SIRT1(LEDEPDVPERAGG)


Description: Imai et al. have found that S. cerevisiae Sir2p and its higher eukaryotic orthologs are novel nicotinamide adenine dinucleotide (NAD)-dependent histone/protein deacetylases. Sir2 proteins promote longevity in yeast and in C. elegans by silencing rDNA and regulating the insulin/IGF-1 signaling pathway, respectively. The enzymatic activities and functions of Sir2 proteins are highly conserved in evolution. In 2001, Vaziri, H. et al. have found that mammalian Sir2 negatively regulates the p53 function by physically interacting with and deacetylating the protein. This aspect of Sir2 function may connect various cellular damages, such as oxidative stress, to aging and carcinogenesis.

Additional Text


Confirmed by western blotting


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