Anti-Human IRF-3 (S386 Phosphorylated) Rabbit IgG Affinity Purify

Catalogue Number: 18783-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 100 ug, 10 ug
Host name:
Clone:
Isotype:
Immunogen: Synthetic peptide of the Phosphorylated C-terminal part of human IRF-3(RVGGAS(pS)LEN)

Description

Description: Interferon Regulatory Factor-3 (IRF-3) is the gene coding for a regulatory factor that mediates the action of IL-1, TNFα and LPS. It is reported that IRF-3 controls the production of interferons and chemokines in virus infected cells, by a posttranslational mechanism that involves virus induced phosphorylation, protein dimerization, cytoplasmic to nuclear translocation and stimulation of responsive genes. Furthermore, it is reported that the chemokine RANTES, an important physiological inhibitor of HIV replication, is controlled by IRF-3 activation. IRF-3 is ubiquitously expressed in its inactive form in the cytoplasm. Viral infection induces phosphorylation of the Ser 386 in IRF-3 by IRF-3 kinase (IKK-i/ε, TBK-1). This phosphorylation induces dimerization of IRF-3 and association with the coactivators CBP/p300, and the complex activates the target genes in the nucleus.

Price
280.00


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