Catalogue Number: 18825-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Physical state:||Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3|
|Type:||Polyclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Immunogen:||Synthetic peptide of the C terminal part of mouse Claudin-2 (SSPRSAQQPKAKSEFNS)|
Description: The tight junction is identified as a belt-like region in which two lipid-apposing membranes lie close together (tight junction strands). Tight junction strands of the adjacent cells form tightly connected pairs. The proteins involved in the formation of tight junctions are divided into two categories: 1) integral membrane proteins, such as occludin, claudin and junctional adhesion molecule, JAM and 2) peripheral membrane proteins (cytoplasmic plaque proteins), MAGUK (membrane-associated guanylate kinase) homologue proteins, such as ZO-1, 2, 3, cingulin, symplekin, 19B1, and AF-6. In human, the claudin superfamily consists of at least 18 members, which are involved on paracellular transport as structural and functional components of tight junction. Claudins are directly associated with ZO-1, 2 and 3 and indirectly with AF-6 and cingulin. It is known that Claudin-1, -2, -6, -7, -15 are distributed at liver or kidney and Claudin-5 is distributed at vascular endothelial cells in mouse, respectively.
Claudin-2 specific. Not cross-react with Claudin-1, -3, -4, -5, -6, -7 and -8. (This confirmed by western blotting using each transfectant.)