Anti-Human DNMT-1 (DNA Methyltransferase-1) Rabbit IgG AffinityPurify 18871
Catalogue Number: 18871-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 10 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide of the C terminal part of Human DNMT-1 (MLAKARESASAKIKE) |
| Application: | WB |
Description
Description: The DNMT-1 is one of the enzymes responsible for methylation. Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. It is identified three families of mammalian DNA methyltransferase genes, which include DNMT-1, DNMT-2 and DNMT-3. The DNMT-1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.
Additional Text
Purification
Affinity Purified
Antibody Clonality
Polyclonal
18871 Datasheet
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