Anti-Human DNMT-1 (DNA Methyltransferase-1) Rabbit IgG Affinity Purify

Catalogue Number: 18871-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 100 ug, 10 ug
Host name:
Clone:
Isotype:
Immunogen: Synthetic peptide of the C terminal part of Human DNMT-1 (MLAKARESASAKIKE)

Description

Description: The DNMT-1 is one of the enzymes responsible for methylation. Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. It is identified three families of mammalian DNA methyltransferase genes, which include DNMT-1, DNMT-2 and DNMT-3. The DNMT-1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.

Additional Text

Specificity

Confirmed by western blotting using HeLa, SY and HT-29 cells.

Price
280.00


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