Anti-Human Tob (Phosphorylated) Rabbit IgG Affinity Purify

Catalogue Number: 18911-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Type:Polyclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Unit(s): 100 ug
Host name:
Clone:
Isotype:
Immunogen: Synthetic peptide of human Tob protein (phosphorylated)(ASSVSS(pS)P(pS)PPFGHS)

Description

Description: Tob is a member of an emerging family of genes with anti-proliferative function. Tob is rapidly phosphorylated at Ser 152, Ser 154, and Ser 164 by Erk1 and Erk2 upon growth-factor stimulation. Tob inhibits cell growth by suppressing cyclin D1 expression, which is canceled by Erk1- and Erk2-mediated Tob phosphorylation. In recent, it is reported that mutant forms of Tob, in which serines are replaced by
glutamic acids to mimic phosphorylation, show a much reduced ability to inhibit the cell cycle progression to S phase from G0/G1 phase, as compared with wild-type Tob, indicating that ERK phosphorylation negatively regulates the anti-proliferative function of Tob.

Additional Text

Specificity

Confirmed by western blotting using transfectant cells.