2',3'-cGAMP, sodium salt

Catalogue Number: 20313-AAT

Manufacturer:	AAT Bioquest
Shelf Life:	12 months
Type:	Media Supplements
Shipping Condition:	Blue Ice
Unit(s):	100 ug

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Datasheets

Description

Description: 2',3'-cGAMP or cGAMP (Cyclic guanosine monophosphate"adenosine monophosphate) is produced in mammalian cells by cGAS (cGAMP synthase) from ATP and GTP upon cytosolic DNA stimulation. cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP. 2',3'-cGAMP is also referred to as noncanonical" cGAMP due to the presence of the atypical 2'-5' phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 3',3'-cGAMP, 2'3'-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β. Structural and functional studies revealed that noncanonical 2'3'-cGAMP is distinct from the canonical 3'3'-cGAMP produced by bacteria. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP. cGAMP has also been shown to be an effective adjuvant that boosts the production of antigen-specific antibodies and T cell responses in mice. cGAMP demonstrates antiviral functions in the cell where it is produced, it can cross cell membranes by passive diffusion to have some effects on neighboring cells.

Additional Text

Storage Note

Freeze (< -15 °C); Minimize light exposure;|12 months

20313 MSDS

20313 Protocol

Price

£316.00

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