2',3'-cGAMP-Biotin conjugate

Catalogue Number: 20316-AAT

Manufacturer:	AAT Bioquest
Shelf Life:	12 months
Type:	Probes
Shipping Condition:	Blue Ice
Unit(s):	100 ug

Overview
Datasheets

Description

Description: 2',3'-cGAMP or cGAMP (Cyclic guanosine monophosphate"adenosine monophosphate) is produced in mammalian cells by cGAS (cGAMP synthase) from ATP and GTP upon cytosolic DNA stimulation. cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP. 2',3'-cGAMP is also referred to as noncanonical" cGAMP due to the presence of the atypical 2'-5' phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 3',3'-cGAMP, 2'3'-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β. This biotin-labeled cGAMP provides an excellent probe for developing assays and test for detecting cGAMP and monitoring its activity.

Additional Text

Storage Note

Freeze (< -15 °C); Minimize light exposure;|12 months

20316 MSDS

20316 Protocol

Price

£1,011.00

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