Podoplanin (Glycoprotein 36, PA2.26 Antigen, Aggrus)
Catalogue Number: 207347-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a lyophilized powder. Reconstitute with sterile dH2O to 0.1-1mg/ml. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Hamster |
| Clone: | RTD4E10 |
| Isotype: | IgG |
| Immunogen: | Mouse thymic stromal cell line. |
| Application: | ELISA, IP, WB, IHC |
Description
Description: Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Recognizes mouse Podoplanin. Does not cross-react with human.
Purification
Protein G purified
Antibody Clonality
Monoclonal
207347 Datasheet
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DELIVERY
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