DUX4 (DUX10, Double Homeobox Protein 4, Double Homeobox Protein 10) (AP)

Catalogue Number: 207573-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol. Labeled with Alkaline Phophatase (AP).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	P2B1
Isotype:	IgG1
Immunogen:	Recombinant GST fusion protein corresponding to a 76aa fragment of human DUX4 at C-terminus.
Application:	IF, WB, IHC

Overview
Datasheets

Description

Description: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD).

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes human DUX4. It does not cross-react with DUX4c.

Accession Number

NP_149418.3

Purification

Protein G purified

Antibody Clonality

Monoclonal

207573 Datasheet

Price

£853.00

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