Mdc1 (Mediator of DNA Damage Checkpoint Protein 1, 6820401C03, AA413496, Nfbd1, mKIAA0170) (PerCP)

Catalogue Number: 207790-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol. Labeled with PerCP.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	P2B11
Isotype:	IgG1
Immunogen:	Recombinant GST fusion protein corresponding to mouse Mdc1 at C-terminal.
Application:	IF, WB

Overview
Datasheets

Description

Description: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 By similarity.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes mouse Mdc1. Species Crossreactivity: bovine, chimpanzee and human

Accession Number

NP_001010833.2

Purification

Protein G purified

Antibody Clonality

Monoclonal

207790 Datasheet

Price

£806.00

-

Quantity
Unit Size

Find out about delivery