Aggrecan (AGC1, CSPG1, MSK16, ACAN) (MaxLight 490)

Catalogue Number: 214472-ML490-USB

Manufacturer:United States Biological
Physical state:Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490.
Type:Monoclonal Primary Antibody - Conjugated
Alias:AGC1|AGCAN|aggrecan core protein|cartilage-specific proteoglycan core protein|chondroitin sulfate proteoglycan core protein 1|CSPG1|CSPGCP|large aggregating proteoglycan|MSK16|SEDK|SSOAOD
Shipping Condition:Blue Ice
Unit(s): 100 ul
Host name: Mouse
Clone: 7D4
Isotype: IgG1
Immunogen: Purified human articular cartilage aggrecan.
Application: IP, WB, IHC, FLISA

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Aggrecan, is a proteoglycan and member of the aggrecan/versican proteoglycan family, which forms a major component of the extracellular matrix (ECM) of both cartilage and the central nervous system (CNS). Studies using a panel of core protein-directed antibodies against human aggrecan, revealed the distribution of different aggrecan isoforms within the CNS, and sub-divided the isoforms into clusters 1-5 accordingly. These studies also showed a difference in the relative abundance of these isoforms when comparing brain and cartilage tissues (Virgintino et al. 2009).

Additional Text

Gene ID

176

Gene Name

ACAN

Specificity

Recognizes human Aggrecan. Species Crossreactivity: bovine. Does not cross-react with chicken, fish or rat.

Purification

Protein G purified

Uniprot ID

P16112

Antibody Clonality

Monoclonal