CD266 (TWEAK-R, TWEAK Receptor, Fn14) (MaxLight 490)
Catalogue Number: 214626-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | ITEM-4 |
| Isotype: | IgG2b |
| Immunogen: | Human CD266 transfected P815 cells |
| Application: | FC, WB, IHC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. CD266, otherwise known as Fn14/TWEAK Receptor, a 14kD type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumors. The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and studies have shown that CD255-induced apoptosis of some tumor cell lines is mediated by CD266 (Nakayama et al. 2003).
Additional Text
Gene ID
51330
Gene Name
TNFRSF12A
Uniprot ID
Q9NP84
Specificity
Recognizes human CD266. Species Crossreactivity: Mouse, rat
Purification
Protein G purified
Antibody Clonality
Monoclonal
214626-ML490 Datasheet
SUPPORT
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DELIVERY
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