CD276 (B7-H3) (FITC)
Catalogue Number: 214636-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rat |
| Clone: | MJ18 |
| Isotype: | IgG1 |
| Immunogen: | Mouse IgG2a Fc-CD276 aa1-242 |
| Application: | FC |
Description
Description: CD276, otherwise known as B7-H3, is a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma (Nagashima et al. 2008).
Additional Text
Gene Name
CD276
Purification
Protein G purified
Uniprot ID
Q8VE98
Gene ID
102657
Antibody Clonality
Monoclonal
214636 Datasheet
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