Factor VIII (APC)
Catalogue Number: 214824-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | AHF|antihemophilic factor|coagulation factor VIII|coagulation factor VIII A1 domain|coagulation factor VIII C2 domain|coagulation factor VIII, procoagulant component|coagulation factor VIIIc|DXS1253E|F8B|F8C|factor VIII F8B|FVIII|HEMA |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | RFF-VIIIC/10 |
| Isotype: | IgG1 |
| Immunogen: | Affinity purified human Factor VIII. |
| Application: | ELISA, WB, RIA |
Description
Description: Factor VIII is an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause hemophilia A, a disorder characterized by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries.
Additional Text
Gene Name
F8
Uniprot ID
P00451
Gene ID
2157
Specificity
Recognizes human Factor VIII.
Purification
Protein G purified
Antibody Clonality
Monoclonal
214824-APC Datasheet
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