High Mobility Group Protein B1 (HMGB1) (HRP)

Catalogue Number: 214889-HRP-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with horseradish peroxidase (HRP).
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	high mobility group protein B1\|amphoterin\|high mobility group protein 1\|Hmg1\|HMG-1\|p30\|SBP-1
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Hamster
Clone:	HMG1-5H6
Isotype:	IgG
Immunogen:	Recombinant mouse HMGB1.
Application:	FC, IF, WB

Overview
Datasheets

Description

Description: HMGB1 is one of the signature danger signals of endogenous cellular injury, and is released outside the cell by necrotic and inflammatory cells to act as a chemoattractant for immature dendritic cells (DCs), promoting their maturation. DCs can also secrete HMGB1, promoting proliferation and Th1 polarization of interacting T cells. Cellular injury resulting in necrosis, leads to passive HMGB1 release, and microbes or pro-inflammatory cytokines may later stimulate active release from APCs. HMGB1 is emerging as a prime specific marker and regulator of necrotic cell death, possibly through the PI3KC3-MEK-ERK pathway. It interacts directly with the autophagy protein Beclin-1, and binds to receptors, such as RAGE on endothelial cells, and Toll-like receptors on macrophages. Studies identifying microtubule-associated protein 1 light chain 3 (LC3) lipidation and redistribution, coupled with the accumulation of autophagosomes and autolysosomes, have shown an important role for HMGB1 release in sustaining autophagy. Studies have also shown that HMGB1 released after chemotherapy treatment is a critical regulator of autophagy, and a potential drug target for therapeutic interventions in leukemia.

Additional Text

UniProt ID

P63158

Specificity

Recognizes mouse High Mobility Group Protein B1. Species Crossreactivity: Rat, human, hamster

Purification

Protein G purified

Gene ID

100862258; 15289

Gene Name

Gm21596, Hmgb1

Antibody Clonality

Monoclonal

214889-HRP Datasheet

Price

£832.00

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