Lipoprotein Lipase (LDL) (PE)
Catalogue Number: 214978-PE-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 5D2 |
| Isotype: | IgG1 |
| Immunogen: | Purified bovine milk lipoprotein lipase. Epitope: aa380-410 |
| Application: | ELISA, IP, WB |
Description
Description: Lipoprotein lipase (LPL) is a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. LPL is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Mouse anti Lipoprotein Lipase antibody, has been shown to inhibit the activity of human LPL (Chang et al. 1998), and is widely used in human studies. This can be used in an indirect ELISA, or as the capture antibody in a sandwich ELISA with a detection reagent. Detects a band of ~53kD using partially purified LPL from postheparin plasma.
Additional Text
Specificity
Recognizes bovine lipoprotein lipase. Species Crossreactivity: Chicken, guinea pig, human, rat
Purification
Protein G purified
Antibody Clonality
Monoclonal
214978-PE Datasheet
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