Lipoprotein Lipase (LPL) (Biotin)

Catalogue Number: 214981-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 1% BSA, 0.09% sodium azide. Labeled with Biotin.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	5D2
Isotype:	IgG1
Immunogen:	Purified bovine milk lipoprotein lipase. Epitope: aa380-410
Application:	ELISA, IP, WB

Overview
Datasheets

Description

Description: Lipoprotein lipase (LPL) is a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. LPL is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Mouse anti Lipoprotein Lipase antibody, has been shown to inhibit the activity of human LPL (Chang et al. 1998), and is widely used in human studies. This can be used in an indirect ELISA, or as the capture antibody in a sandwich ELISA with a detection reagent. Detects a band of ~53kD using partially purified LPL from postheparin plasma.

Additional Text

Gene Name

LPL

Specificity

Recognizes bovine lipoprotein lipase. Species Crossreactivity: Chicken, guinea pig, human, rat

Purification

Protein G purified

Uniprot ID

P11151

Gene ID

280843

Antibody Clonality

Monoclonal

214981 Datasheet

Price

£592.00

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