TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650)

Catalogue Number: 215168-ML650-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™650.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	AA816106\|AU019358\|AU019662\|C78111\|G9D3\|T-cell immunoglobulin and mucin domain-containing protein 2\|T-cell immunoglobulin mucin receptor 2\|T-cell membrane protein 2\|Tim2\|TIM-2\|TIMD-2
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rat
Clone:	RMT2-25
Isotype:	IgG2a
Immunogen:	Tim-2-Ig, consisting of aa1-230 from mouse Tim-2, coupled with the Fc portion of mouse IgG2a.
Application:	IP, WB

Overview
Datasheets

Description

Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Tim-2 (T-cell immunoglobulin mucin 2), a transmembrane glycoprotein and member of the immunoglobulin superfamily, is expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells. Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation. Studies using TIM-2 in mouse have shown that signaling by Tim-2 can influence the proliferation and antibody production of B cells, during early phase CIA (collagen-induced arthritis) (Kawamoto et al. 2011). TIM-2 has been shown to significantly enhance the proliferation of stimulated splenic B cells in vitro.

Additional Text

Specificity

Recognizes mouse Tim-2.

Purification

Protein G purified

Gene ID

171284

Uniprot ID

Q8R183

Gene Name

Timd2

Antibody Clonality

Monoclonal

215168-ML650 Datasheet

Price

£832.00

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