TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 650)
Catalogue Number: 215171-ML650-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™650. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | HAVcr-2|hepatitis A virus cellular receptor 2 homolog|T-cell immunoglobulin and mucin domain containing 3|T-cell immunoglobulin and mucin domain-containing protein 3|T-cell immunoglobulin mucin receptor 3|T-cell membrane protein 3|Tim3|TIM-3|Timd3|TIMD-3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rat |
| Clone: | RMT3-23 |
| Isotype: | IgG2a |
| Immunogen: | Tim-3-Ig, consisting of aa1-191 from mouse Tim-3, coupled with the Fc portion of mouse IgG2a. |
| Application: | IF, IHC |
Description
Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. T-cell immunoglobulin mucin 3, a transmembrane glycoprotein and member of the immunoglobulin superfamily, is preferentially expressed by differentiated CD4+ Th1 cells and CD8+ Tc1 (cytotoxic) cells, but not by CD4+ Th2 cells or CD8+ Tc2 cells. Tim-3 acts as a negative regulator of Th1-mediated inflammatory diseases including GVHD, type I diabetes, and EAE (experimental autoimmune encephamyelitis), promotes immunological tolerance, and is a receptor for galectin-9, shown to induce cell death of Th1 cells in vitro. Tim-3 is also involved in the regulation of macrophage activation, acts as a phagocytic receptor, and has been shown to recognize apoptotic cells via the IgV domain. Studies have shown Tim-3 significantly inhibits the efficient phagocytosis of apoptotic cells by PEMs (peritoneal exudate Mac1+ cells) ( Nakayama et al. 2009).
Additional Text
Gene Name
HAVCR2
Specificity
Recognizes mouse TIM-3.
Purification
Protein G purified
Uniprot ID
Q8VIM0
Gene ID
171285
Antibody Clonality
Monoclonal
215171-ML650 Datasheet
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