TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC)

Catalogue Number: 215175-APC-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	B430010N18Rik\|smuckler\|spleen, mucin-containing, knockout of lymphotoxin protein\|T-cell immunoglobulin and mucin domain-containing protein 4\|T-cell immunoglobulin mucin receptor 4\|T-cell membrane protein 4\|Tim4\|TIM-4\|TIMD-4
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rat
Clone:	RMT4-54
Isotype:	IgG2a
Immunogen:	Tim-4-Ig, consisting of aa1-288 from mouse Tim-4, coupled with the Fc portion of mouse IgG2a.
Application:	IF, IHC

Overview
Datasheets

Description

Description: Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, is exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production. Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma. Studies have shown that Tim-4 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) see Nakayama, M. et al. . for details.

Additional Text

Gene Name

TIMD4

Specificity

Recognizes mouse TIM-4.

Purification

Protein G purified

Gene ID

276891

Uniprot ID

Q6U7R4

Antibody Clonality

Monoclonal

215175-APC Datasheet

Price

£799.00

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