CD86 (B7-2)
Catalogue Number: 216337-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rat |
| Clone: | 14L241 |
| Isotype: | IgG2 |
| Immunogen: | LPS stimulated Mouse B-Cells. |
| Application: | FC, IP, IHC |
Description
Description: CD86 is an 80kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells and astrocytes. CD86 along with CD80 are the ligands of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Additional Text
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
216337 Datasheet
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