IGFBP-2 ELISA (96 wells), "RUO"
Catalogue Number: 22-BP2HU-E01-ALP
| Manufacturer: | Alpco Diagnostics |
| Type: | Human ELISA Kit |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 96 Wells |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: | |
| Range: | 2 - 80 ng/mL |
| Sensitivity: | 0.2 ng/mL |
| Sample type: | Cell Culture, Milk, Plasma, Saliva, Serum |
| Sample size: | 15 µL |
| Application: | ELISA, IA |
Description
Description: Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of growth hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of fetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGFforms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism.
Additional Text
Short Description
The IGFBP-2 ELISA is for the quantitative determination of IGFBP-2 in human serum, plasma, saliva, CSF, amniotic fluid, breast milk, and cell culture medium. For Research Use only. Not For In Vitro Diagnostic Use. Dynamic range 2-80 ng/mL Sensitivity 0.2 ng/mL Sample size 15 uL
Storage Note
store at 2-8C
22-BP2HU-E01 Protocol
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