CD44 (H-CAM, PGP-1) (MaxLight 490)
Catalogue Number: 227421-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rat |
| Clone: | YKIX337.8.7 |
| Isotype: | IgG2a |
| Immunogen: | Concanavilin A activated Canine T cells. |
| Application: | IHC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Recognises canine CD44, also known as H-CAM, a single-pass type 1 membrane of ~90kD expressed by most leucocytes and epithelial cells. CD44 expression is markedly increased upon cell activation (Alldinger et al. 2000). CD44 is involved in cell-cell, cell adhesion and cell migration and is the principal cellular receptor for hyaluronate via it's LINK domain, additionally CD44 also interacts with other ligands including collagens and metalloproteinases. Studies have demonstrated that altered CD44 expression is detected in a many forms of invasive and metasic cancers, CD44 expression has been observed on canine mammary and melanocytic tumors (Serra et al. 2004).
Additional Text
Specificity
Recognizes canine CD44.
Purification
Protein G purified
Uniprot ID
Q28284
Antibody Clonality
Monoclonal
227421-ML490 Datasheet
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