Delta like Protein 4 (DLL4) (PE)

Catalogue Number: 227436-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a lyophilized powder in PBS, 1% BSA, 5% sucrose, 0.09% sodium azide. Reconstitute with 1ml ddH2O. Labeled with R-Phycoerythrin (PE).
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Delta4\|delta-like 4\|delta-like protein 4\|drosophila Delta homolog 4
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Hamster
Clone:	HMD4-2
Isotype:	IgG
Immunogen:	Recombinant protein corresponding to mouse DLL4.
Application:	FC

Overview
Datasheets

Description

Description: Delta-like protein 4 (DLL4) is one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation ofe cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL4 is expressed by vascular endothelium, and plays a vital role in embryonic vascular development. DLL4 signalling has been shown to play a role in the angiogenesis of clear-cell renal tumors, and pancreatic, bladder and colonic cancer. Studies have shown that DLL4 expression in endothelium cells, can be up-regulated by vascular endothelial growth factor (VEGF) and basic-FGF, and by HIF1 alpha, and that blockade of DLL4 inhibits tumor growth by promoting non-productive angiogenesis.

Additional Text

Gene Name

DLL4

Specificity

Recognizes mouse delta-Like Protein 4.

Purification

Protein G purified

Uniprot ID

Q9JI71

Gene ID

54485

Antibody Clonality

Monoclonal

227436 Datasheet

Price

£715.00

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