MHC Class I (PE)
Catalogue Number: 227447-PE-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | VPM19 |
| Isotype: | IgG1 |
| Immunogen: | Sheep T cells. |
| Application: | IP, WB, IHC |
Description
Description: Recognizes the ovine homologue of the human MHC Class I, a monomorphic determinant expressed on the heavy chain of sheep MHC Class I, (OLA Class I). The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In sheep, this is often referred to as the ovine leukocyte antigen (OLA) region. Ovine MHC Class I functions in the recognition and presentation of foreign antigens to T-cells. Ovine MHC Class I is a membrane glycoprotein with a molecular weight of ~44kD, expressed on the cell surface of all peripheral blood leucocytes. Has been in used in studies on a number of domestic animal diseases, in particular Maedi Visna virus infection, a disease of significant inportance in commercial sheep flocks (Lee et al. 1996, Ryan et. al. 2000 and Wu et. al. 2008). Has been cited as recognising MHC class I in some other species and has been used in a study of Feline herpes virus infection (Montagnaro et. al. 2009).
Additional Text
Specificity
Recognizes sheep MHC Class I. Species Crossreactivity: feline.
Purification
Protein A purified
Antibody Clonality
Monoclonal
227447-PE Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations