CD69 (VEA, AIM, EA1, MLR3, gp34/28, Leu-23) (APC)
Catalogue Number: 228156-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, sodium azide. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Hamster |
| Clone: | H1.2F3 |
| Isotype: | IgG |
| Immunogen: | Mouse dendritic epidermal cell line Y245. |
| Application: | FC |
Description
Description: CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39kD. It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. Although not detectable on resting lymphocytes, its expression is rapidly upregulated upon activation of T, B and NK cells, and neutrophils. Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. The monoclonal antibody augments PMA-induced T-cell proliferation and induces redirected lysis of Fc receptor-bearing target cells by NK cells.
Additional Text
Specificity
Recognizes mouse CD69.
Purification
Purified
Antibody Clonality
Monoclonal
228156 Datasheet
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