CD8 (PE/Cy5)
Catalogue Number: 228167-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, sodium azide. Labeled with R-Phycoerythrin (PE/Cy5). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | CT-8 |
| Isotype: | IgG1 |
| Immunogen: | Chicken thymocytes and Ig-negative blood leukocytes. |
| Application: | FC |
Description
Description: In the chicken, the CD8 molecule is present in two forms - (i) a homodimer of two a chains and (ii) a heterodimer of an a chain and a b chain. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8a- and CD8b-chains, a relatively large proportion of the CD8+ TCRgd cells in the spleens of embryos and young chicks express only the a-chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved but there is a population of TCRgd CD8ab cells in the chicken that is not found in rodents. Chicken CD8 is expressed on approximately 80% of thymocytes, 15% of blood mononuclear cells, and 50% of spleen cells but less than 1% of cells in the bursa and bone marrow. Recognizes the CD8a chain and has been shown to react to a polymorphic determinant in turkey.
Additional Text
Specificity
Recognizes Chicken CD8a. Species Crossreactivity: Turkey, Guinea Fow
Purification
Purified
Antibody Clonality
Monoclonal
228167 Datasheet
SUPPORT
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