Fas Ligand (FITC)
Catalogue Number: 228200-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, sodium azide. Labeled with Fluorescein isothiocyanate (FITC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | SB93a |
| Isotype: | IgG2b |
| Immunogen: | Recombinant protein corresponding to human Fas Ligand. |
| Application: | FC, IP, WB |
Description
Description: Fas Ligand (CD178) is a 40kD type II transmembrane protein that is a member of the tumor necrosis factor superfamily. This well characterized potent apoptotic factor is utilized by cytotoxic T cells and natural killer cells to selectively kill virus infected and tumorigenic cells.1,2 Moreover, studies indicate that Fas Ligand is an important regulator in immune homeostasis where it has been shown to down-regulate immune responses during activation-induced cell death.3 Fas Ligand initiates apoptosis by binding to its receptor (CD95) on target cells which facilitates recruitment of numerous signaling proteins to form a death inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase-8.4 The monoclonal antibody detects a band at ~40kD, corresponding to the transmembrane (insoluble) form of Fas Ligand.
Additional Text
Specificity
Recognizes native and recombinant human Fas Ligand.
Purification
Purified
Antibody Clonality
Monoclonal
228200 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations