Spi2A (Spi2A, Serine Protease Inhibitor 2A, Serine Protease InhibitorA3G, Serpin 2A, Serpin A3G, Serpina3g)
Catalogue Number: 254297-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 0.09% sodium azide. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Hamster |
| Clone: | MoFo29.2 |
| Isotype: | IgG2b |
| Immunogen: | Synthetic peptide corresponding to Mouse Spi2A aa406-426 (C terminal). Sequence: NPERSTNFPNGEGASSQRC |
| Application: | WB |
Description
Description: Spi2A is a serine and cysteine protease inhibitor. It can inhibit lysosomal papain-like proteases including the cathepsins B G H K L and V. It is ineffective against elastase granzyme A granzyme B or caspases 3 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells.
Additional Text
Specificity
Recognizes Spi2A Species Crossreactivity: Mouse
Purification
Protein G purified
Antibody Clonality
Monoclonal
254297 Datasheet
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