TNFR Type II (CD120b, TNF R Type II/p75, TNFRII, p75, TNFR80, TNFRSF1B, TNFR Superfamily, 75kD) (Low Endotoxin, Azide Free)
Catalogue Number: 257186-USB
| Manufacturer: | United States Biological |
| Preservative: | Low Endotoxin, Azide Free |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Hamster |
| Clone: | TR75-54.7 |
| Isotype: | IgG |
| Immunogen: | E. coli -expressed mouse Type II TNFR |
| Application: | ELISA, FC, IP, WB |
Description
Description: CD120b is a 75kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-a and LT-a (also known as TNF-b). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-a or LT-a trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The antibody has been shown to block ligand-induced receptor signaling.
Additional Text
Specificity
Recognizes mouse TNFR Type II.
Purification
Affinity Purified
Antibody Clonality
Monoclonal
257186 Datasheet
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