Human Fibulin-5/DANCE Assay Kit - IBL
Catalogue Number: 27121-IBL
| Manufacturer: | IBL - (Immuno-Biologicals Laboratories Co Ltd) |
| Type: | Human ELISA Kit |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 96 well plate |
| Range: | 0.08 ~ 5.0 ng/mL |
| Sensitivity: | |
| Sample type: | Cell Culture Supernatant, Plasma |
| Sample size: |
Description
Description: DANCE was identified as a ligand of integrins expressed mainly in arteries during embryogenesis and was named developmental arteries and neural crest EGF-like /DANCE. It is also called fibulin-5 and is a member of fibulin-family. Fibulin-5/DANCE is a secreted protein of 448 amino acids and 66kDa. It contains a RGD (arginine-glycine-asparticacid) motif in the N-terminal ragion and binds to integrins α5β1, αvβ3 and αvβ5. The expression of mRNA is augmented in smooth muscle cell, fibroblasts and endothelial cells of injured vascular tissues. Fibulin-5-deficient mice recapitulate human aging phenotypes, such as loose skin (cutis laxa), emphysematous lungs, and stiff ateries. It is known that destruction and degradation of elastic fibers directly cause many aging-related disorders like these. Disorganized elastic fibers were observed in the fibulin-5-deficient mice and indicating that fibulin-5/DANCE is an essential protein for elastogenesis. This product is an ELISA kit wich can measure human fibulin-5/DANCE. The control set is available for sale on request.
27121 Datasheet
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