Catalogue Number: 28011-IBL
|Manufacturer:||IBL - (Immuno-Biologicals Laboratories Co Ltd)|
|Physical state:||Lyophilized product from 1% BSA in PBS containing 0.05% NaN3|
|Type:||Polyclonal Primary Antibody - Unconjugated|
|Shipping Condition:||Blue Ice|
|Unit(s):||100 ug, 10 ug|
|Immunogen:||Synthetic peptide of the middle part of Human Raptor(IRKEREWRFLRNSRVRRQA)|
Description: Raptor (regulatory associated protein of mTOR) is an about 150 kDa protein which has HEAT repeats and WD40 repeats, and it is identified as an mTOR binding protein. It is conserved over species and widely expressed in a variety of cells, and is also one of configuration factors of mTORC1/mTOR complex 1, which controls proteosynthesis and/or growth of cells along with mLST8. Raptor binds to p70 S6 kinase or 4E-BP1 (eukaryotic translation initiation factor 4E binding protein 1) which is a substrate of mTOR, through the mediation of TOS (TOR signaling) motif, and it plays an important role as a scaffold protein in phosphorylation of the substrate by mTOR.